Milestone-Proposal:The first magnetic resonance image (MRI)
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This Proposal has been approved, and is now a Milestone
To the proposer’s knowledge, is this achievement subject to litigation? No
Is the achievement you are proposing more than 25 years old? Yes
Did the achievement provide a meaningful benefit for humanity? Yes
Was it of at least regional importance? Yes
Has an IEEE Organizational Unit agreed to pay for the milestone plaque(s)? Yes
Has an IEEE Organizational Unit agreed to arrange the dedication ceremony? Yes
Has the owner of the site agreed to have it designated as an IEEE Milestone? Yes
Year or range of years in which the achievement occurred:
September 2, 1971. Paul Lauterbur’s original idea for obtaining two-dimensional and three- dimensional images showing the distribution of magnetic nuclei relaxation times and diffusion coefficient was recorded in his notebook. A copy of this entry is found in Appendix A. His subsequent experiments resulted in reducing the first two- dimensional magnetic resonance image (MRI) and the results were published in the March 16, 1973 issue of Nature. Appendix B is a copy of that article.
Title of the proposed milestone:
The First Nuclear Resonance Image (MRI),1973
Plaque citation summarizing the achievement and its significance:
Two-dimensional images of the distribution of magnetic nuclei such protons were achieved for the first time at SUNY Stony Brook in 1973. The use of magnetic field gradients enabled the proton distribution of a substance to especially encoded. This demonstration paved the way for magnetic resonance imaging to have world-wide use I medical diagnostics.
In what IEEE section(s) does it reside?
Long Island Section
IEEE Organizational Unit(s) which have agreed to sponsor the Milestone:
IEEE Organizational Unit(s) paying for milestone plaque(s):
Unit: Long Island Section
Senior Officer Name: Marjineh Issapour
IEEE Organizational Unit(s) arranging the dedication ceremony:
Unit: Long Is;and Section
Senior Officer Name: Marjineh Issapour
Unit: Stony Brook University
Senior Officer Name: Dr Mark Schweitzer
IEEE section(s) monitoring the plaque(s):
IEEE Section: Long Island Section
IEEE Section Chair name: Marjineh Issapour
Proposer name: Jesse Taub
Proposer email: Proposer's email masked to public
Street address(es) and GPS coordinates of the intended milestone plaque site(s):
Chemistry Building o f the University. of Stony Brook ,John S Toll Road 100 Nicolls Road 104, Chemistry Stony Brook ,NY 11790-3400
Latitude N40 54.984, Longitude W73.07.435
Please give the address(es) of the plaque site(s) (GPS coordinates if you have them). Also please give the details of the mounting, i.e. on the outside of the building, in the ground floor entrance hall, on a plinth on the grounds, etc. If visitors to the plaque site will need to go through security, or make an appointment, please give the contact information visitors will need. It will be housed in the lobby of the Chemistry Building of the University of Stony Brook near where Lauterbur's original equipment is displayed.
Are the original buildings extant?
Details of the plaque mounting:
It will be on the ground floor and mounted on a wall in the lobby
How is the site protected/secured, and in what ways is it accessible to the public?
The wall mounting will be secure.. The place where it will be mounted is available to the general public.
Who is the present owner of the site(s)?
University of Stony Brook
Lauterbur’s technique for obtaining a two-dimensional magnetic resonance image was first disclosed in an article in the March 16, 1973 issue of Nature (Appendix B).
Prior to his effort when NMR measurements were made on substances, there was no way to identify where the resonances occurred because a fixed magnetic field was applied. He realized that if a linear radiant was added to the fixed magnetic field it would be possible to spatially encode the substance in one dimension. By rotating this linearly varying magnetic field, he could get responses in the other dimension.
This groundbreaking achievement drew on several prior technologies. • Availability of nuclear magnetic resonance (NMR) spectroscopy equipment to measure the properties of chemical substances. • Tomography algorithms previously developed for X-Ray CT scanning. We will briefly review the prior knowledge that Lauterbur needed to accomplish his goal. A. Nuclear Magnetic Resonance (NMR) NMR is a physical phenomenon in which nuclei absorb and re-emit elecromagnetic radiation, typically in the 60-1000 MHz region. This occurs at a specific frequency which is proportional to the applied magnetic field. It can be used to study he properties of a wide range of chemical substances. However, in the case of MRI for medical application, one is usually concerned hydrogen protons contained in water molecules. NMR was first observed by Isadore Rabi in 1938 in gases. Felix Bloch and Edward Purcell demonstrated its use in liquids and solids. They all received Nobel Prizes for their work. The resonant behavior can be observed by applying electromagnetic radiation at the same frequency of the precession of the protons.
B- NMR Equipment Lauterbur’s two-dimensional images were produced by using a Varian A60 NMR spectrometer with coils added to produce magnetic field gradients. A photo of the A60 is found in Appendix C. The slope of the gradient corresponded to 700Hz per cm. The sample to be imaged received electromagnetic (RF) radiation at a nominal frequency of 60MHz. This frequency was varied to get a linear projection. Lauterbur imaged a water tube such that resonant interaction occurred only with the waters hydrogen protons. He then rotated the gradient field at three additional 45degree intervals to obtain sufficient data to construct a satisfactory two-dimensional image. His final step was to construct an image from these data. He realized that the problem had been solved for X-Ray CT scans and suitable algorithms were available. Lauterbur used one described by Gordon and Herman which is found in Appendix D. While he did not do so in his early work, he realized that previously developed Fourier transformed NMR and FFT algorithms could speed up image formation. While the currant MRI equipment is vastly more complex, Lauterbur’s achievement had much to do with spurring these developments. C- Scanning and Transient NMR
While Lauterbur’s original work was done by scanning the RF signal, he noted that transient (Fourier transform) methods could be used as well, as described below.
Since the introduction of a magnetic field gradient will enable the resonance of a substance to be a function of distance; in Lauterbur’s case, he was imaging two 1mm inside diameter glass tubes filled with water. Thus, if we vary the frequency of the applied electromagnetic (RF) energy, we could get a one-dimensional projection of the water. Lauterbur rotated the magnetic field at 3 additional 45 degree intervals. These four linear projections filled up the two-dimensional space. Lauterbur was able to construct a two-dimensional image with the aid of an algorithm developed by Gordon and Herman. (see Appendix E) The algorithm had been developed to obtain two-dimensional images from X-Ray CT scans. The transient method would involve pulse modulation of the RF signal. The pulse width would have to short enough to produce a frequency spectrum that would encompass the maximum shift in resonant frequency due to the gradient magnetic field change. If such a pulse applied to the substance to be imaged and a Fourier transform of the response is performed, it would generate the desired linear projection. Using Fourier transform NMR clearly speeds up the process of determining the image. At the time of Lauterbur’s 1973 Nature article, he used frequency scanning. Fourier NMR was a known technique when he produced the first image and he did indeed use it in his later work. D- Summary While many improvements in speed and image quality have been made since this early work, Lauterbur’s demonstration of two- dimensional imaging was a major spur to make MRI the valuable development to the medical field. Researchers are continuing to find new applications for diagnostic imaging and more exciting discoveries undoubtedly lie ahead.
What obstacles (technical, political, geographic) needed to be overcome?
For Lauterbur to do his experimental work ,he had to modify the Stony Brook University Chemistry Department's NMR spectrometer by adding gradient coils to he instrument .He had to do this after hours and return the instrument to its original state each time. The spectrometer was the Varian A 60. Other than that, he was able to try out his ideas that were expressed in his notes (Appendix A) and achieve his groundbreaking results.
What features set this work apart from similar achievements?
Prior to this work, only one dimensional NMR images had been realized many years earlier. Once Lauterbur showed that 2D imaged could be obtained ,faster and higher resolution images became a reality,mostly due to Mansfield at the University of Nottingham.Lauterbur and Mansfield shared the Nobel Prize for Physiology or Medicine in 2003 for their MRI research..
Appendices A -E which can be found in the Historical Significance portion of this proposal..